Amitriptyline Drug Interactions

The following sections explain in detail the potentially negative interactions that can occur when amitriptyline is combined with any of the drugs listed above.

 

Taking amitriptyline with anticholinergic medications may cause increased side effects. Talk with your healthcare provider before using these medications together, as your dosages may need to be reduced. Since some of these anticholinergic medications are found in over-the-counter medicines, do not treat yourself for the common cold, a cough, or allergies without first talking to your healthcare provider.

 

Taking amitriptyline with barbiturates can increase the risk of side effects, such as drowsiness or dizziness. Your healthcare provider may need to adjust your dose of these medications.

 

Cimetidine (Tagamet)

Taking amitriptyline with cimetidine can increase the level of amitriptyline in your blood, increasing your chance of side effects. Your healthcare provider may need to adjust your dose of these medications.

 

Taking amitriptyline with cisapride can increase your risk of a dangerous arrhythmia, which is an irregular heart rhythm. In general, these two medications should not be taken together.

 

Taking amitriptyline with flecainide can increase the level of amitriptyline in your blood, raising your risk of side effects. Your healthcare provider may need to adjust your dose of these medications.

 

Taking amitriptyline with MAOIs can increase your chance of developing dangerous side effects. Do not take amitriptyline if you have taken an MAOI within the past two weeks.