Amitriptyline Drug Interactions

Phenothiazine Medications
Taking amitriptyline with phenothiazines may increase the level of amitriptyline in your blood, increasing your chance of side effects. If you are taking these medicines together, your healthcare provider may need to lower your dose of amitriptyline.
 
Pressor Medications
Taking amitriptyline with pressor medications can increase your risk of side effects. Your healthcare provider may need to adjust your dose of these medications.
 
Propafenone (Rythmol)
Taking amitriptyline with propafenone can increase the level of amitriptyline in your blood, increasing your chance of side effects. Your healthcare provider may need to adjust your dose of these medications.
 
Disulfiram (Antabuse)
Taking amitriptyline with disulfiram may cause delirium. Your healthcare provider may need to adjust your dose of these medications to avoid this amitriptyline interaction.
 
Quinidine
Taking amitriptyline with quinidine can increase the level of amitriptyline in your blood, increasing your chance of side effects. Your healthcare provider may need to adjust your dose of these medications.
 
SSRI Antidepressants
Taking amitriptyline with SSRI antidepressants can increase the level of amitriptyline in your blood, increasing your chance of side effects. Your healthcare provider may need to adjust your dose of these medications or use caution when switching from one medicine to another.
 
Thyroid Medications
Taking amitriptyline with thyroid medications can increase your risk of amitriptyline side effects. Your healthcare provider may need to adjust your dose of these medications.
 
Tricyclic Antidepressants
Taking amitriptyline with other tricyclic antidepressants can increase your risk of side effects. Your healthcare provider may need to adjust your dose of these medications.
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Amitriptyline Drug Information

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