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Amitriptyline Drug Interactions

A few of the drugs that amitriptyline can potentially interact with include barbiturates, MAOIs, thyroid medications, and cisapride. Amitriptyline drug interactions can increase your risk of developing dangerous side effects, cause heart arrhythmias, or lead to thoughts of suicide, among other things. Therefore, you should be sure to talk with your healthcare provider about any drug interactions with amitriptyline that may apply to you.

 

Amitriptyline Drug Interactions: An Introduction

 Amitriptyline hydrochloride (Elavil®) can potentially interact with many drugs. Some of the drugs that may lead to amitriptyline interactions include:
 
  • Anticholinergic medications, including:
o Atropine
o Belladonna (Donnatal®, B&O Supprettes®, Bellamine S®)
o Clidinium (Librax®)
o Diphenhydramine (Benadryl®, Tylenol PM®)
o Glycopyrrolate (Robinul®)
o Homatropine (Hycodan®)
o Hyoscyamine (Levsin®)
o Scopolamine (Transderm Scop®)
  • Barbiturates, including:
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®).
  •  
  • Cisapride (Propulsid®)
     
  • Flecainide (Tambocor®)
     
  • Monoamine oxidase inhibitors (MAOIs), including:
  • Phenothiazine medications, including:
o Promethazine (Phenergan®)
  • Pressors, including:
o Dopamine (Intropin®)
o Dobutamine (Dobutrex®)
o Epinephrine (Adrenalin®, EpiPen®)
o Norepinephrine (Levophed®).
  • Propafenone (Rythmol®)
     
  • Quinidine
     
  • Disulfiram (Antabuse®)
     
  • SSRI antidepressants, including:
  • Thyroid medications, including:
o Liothyronine (Cytomel®)
o Liotrix (Thyrolar®)
o Levothyroxine (Levoxyl®, Synthroid®, Unithroid®)
o Thyroid (Armour® Thyroid, Nature-Throid®).
  • Alcohol.
     
(Amitriptyline Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;