Depression
Medications
Related eMedTV
Health Channels

Antidepressants

Antidepressants are medications primarily used for treating depression. Examples of this type of drug include SSRIs, SNRIs, and monamine oxidase inhibitors. Since there are so many different kinds to choose from, it is important to consult with your healthcare provider to find the most appropriate medication for your particular situation. Common side effects reported with antidepressants include sleep changes, sexual problems, and appetite changes.

 

What Are Antidepressants?

As you might guess, antidepressants are medications used to treat depression. There are many different types of antidepressants, each with unique advantages and disadvantages. Some of these medications are used to treat a wide variety of conditions, some of which are completely unrelated to depression.
 
(Click Antidepressant Uses for more information on what they are used for, including possible off-label uses.)
 

Types of Antidepressants

There are several types of antidepressants available to treat depression.
 These include newer medications, such as:
 
  • Selective serotonin reuptake inhibitors (SSRIs)
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs)
  • Tricyclic antidepressants
  • Monoamine oxidase inhibitors (MAOIs)
  • Miscellaneous other antidepressants.
     
It is not uncommon for a healthcare provider to try a variety of antidepressants before finding the most effective and best tolerated medication (or combination of medications) for a patient.
 
(Click Types of Antidepressants for more information. See List of Antidepressants for a list of each different type of antidepressant.)
 

How Do They Work?

Generally, most antidepressants work by increasing certain brain chemicals.
 

When and How to Use Antidepressants

Some general considerations for when and how to use these medications include the following:
 
  • Follow the instructions your healthcare provider gives you for your particular antidepressant.
     
  • Be aware that it may take awhile (sometimes as long as a month or two) for your medication to start working. You may develop side effects long before you feel any benefit. Try not to become discouraged by this.
     
  • Be sure to take your dosage at the same time(s) each day to maintain an even level of medication in your blood.
     
  • For antidepressants to work properly, they must be taken as prescribed. Do not stop taking your antidepressant without your healthcare provider's approval (see Antidepressant Withdrawal).
     

Dosage of Antidepressants

Each individual antidepressant has specific dosing recommendations. The dosage of different antidepressants cannot be directly compared (for instance, 10 mg of one antidepressant may just be as "strong" as 500 mg of another antidepressant). Please refer to your specific antidepressant within eMedTV for more information about the dosage of your medication.
 

What Are the Side Effects?

In general, the newer types of antidepressants (such as SSRIs and SNRIs) are less likely to cause side effects than older antidepressants (such as tricyclic antidepressants and MAOIs). However, all antidepressants are capable of causing side effects, which may sometimes be severe. Some of the more well-known antidepressant side effects include:
 
(Click Side Effects of Antidepressants to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)
 

Drug Interactions With Antidepressants

Most antidepressants can interact with many different medications. Some of these interactions can be quite serious. For more information, see the information for your particular antidepressant within eMedTV.
 

What Should I Tell My Healthcare Provider Before Taking Antidepressants?

Although each individual antidepressant carries its own warnings and precautions, in general, you should talk with your healthcare provider prior to using antidepressants if you have:
 
  • Any chronic medical condition
  • Bipolar disorder
  • A history of suicidal thoughts or behaviors
  • Any allergies, including allergies to drugs, foods, preservatives, or dyes.
     
Also, let your healthcare provider know if you:
 
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;