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Aplenzin Drug Interactions
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from eMedTV.comNicotine Patches
Taking Aplenzin while using nicotine patches can cause high blood pressure. Your healthcare provider should monitor your blood pressure if you are taking these medications together.
Orphenadrine
It is thought that orphenadrine may interact with Aplenzin, although the actual significance of this interaction is unknown. Your healthcare provider may need to monitor you more closely and may need to adjust your dose of these medications.
Ritonavir (Norvir) or Lopinavir and Ritonavir (Kaletra)
Ritonavir (whether taken alone or with lopinavir) may increase the metabolism of Aplenzin, leading to decreased levels of Aplenzin in the blood and possibly to decreased effectiveness. Check with your healthcare provider before taking such medications together. You may need a higher Aplenzin dosage, although the maximum recommended dosage should not be exceeded, even if you are taking ritonavir.
Steroids
Taking Aplenzin with intravenous or oral steroids can increase your risk of seizures. Talk to your healthcare provider before taking these medications together.
Tamoxifen (Nolvadex)
At least theoretically, Aplenzin could cause tamoxifen to be less effective. Check with your healthcare provider before taking these medications together.
Theophylline
Taking Aplenzin with theophylline can increase your risk of seizures. Talk to your healthcare provider before taking Aplenzin and theophylline together.
Thiotepa
It is thought that thiotepa may interact with Aplenzin, although the actual significance of this interaction is unknown. Your healthcare provider may need to monitor you more closely and may need to adjust your dose of these medications.
Ticlopidine
Ticlopidine may slow the metabolism of Aplenzin in the body, potentially leading to high levels of Aplenzin and a potentially higher risk of Aplenzin side effects. Check with your healthcare provider before taking these medications together.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD