Aplenzin Warnings and Precautions

Specific Aplenzin Warnings and Precautions

Some warnings and precautions to be aware of prior to taking Aplenzin include the following:
  • Antidepressants (including Aplenzin) may increase the risk of suicidal thoughts or behavior in children, teenagers, and adults (see Depression and Suicide and Antidepressants and Suicide for more information). Therefore, if you notice any changes in symptoms or new symptoms, immediately notify your healthcare provider. Some of these symptoms may include:
    • Anxiety
    • Hostility
    • Agitation
    • Panic
    • Restlessness
    • Hallucinations
    • Extreme hyperactivity
    • Suicidal thoughts or behavior.
  • Before prescribing Aplenzin for depression, your healthcare provider should make sure that you do not have bipolar disorder (instead of depression). Sometimes, the symptoms of bipolar disorder and depression are very similar, and Aplenzin can cause problems in people with bipolar disorder.
  • Aplenzin can increase the risk of seizures (see Aplenzin Seizures). Because of this, there are certain people who should not take Aplenzin, including people with:
Also, people taking certain medications (see Aplenzin Drug Interactions) have a higher risk of seizures. Abruptly stopping alcohol or sedative medications can also increase your risk of seizures.
  • To avoid seizures, you should not take more than 522 mg of Aplenzin per day.


  • Aplenzin has been reported to cause false positives on some amphetamine drug screening tests, even after people have stopped taking Aplenzin.


  • Aplenzin should not be used right after a heart attack. Also, there is some evidence that this antidepressant can cause irregular heart rhythms (arrhythmias) in people with heart disease.
  • Aplenzin can cause liver damage. Also, because the liver and kidneys help to remove Aplenzin from the blood, you should talk to your healthcare provider before taking this medication if you have liver or kidney problems.
  • Aplenzin can cause insomnia, agitation, hallucinations, confusion, and other mental problems, especially in people just starting the medicine. Tell your healthcare provider if you are experiencing any of these problems.
  • Aplenzin can cause weight loss. This can be a problem for some people, especially those who are underweight (see Aplenzin and Weight Loss for more information).
  • Aplenzin can cause allergic reactions. Tell your healthcare provider if you have signs of an allergic reaction, including an unexplained skin rash, itching, hives, trouble breathing, or unexplained swelling.
  • Sometimes, Aplenzin can cause high blood pressure (hypertension), especially in people using nicotine patches. Your healthcare provider should monitor your blood pressure if you are taking this antidepressant. It is not known if Aplenzin causes problems in people who have heart disease or who have recently had a heart attack.
  • Aplenzin is considered a pregnancy Category C medication. This means that it may not be safe to use during pregnancy. Talk to your healthcare provider about the risks and benefits of using Aplenzin during pregnancy (see Aplenzin and Pregnancy for more information).
  • Aplenzin passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using this antidepressant (see Aplenzin and Breastfeeding).
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Aplenzin Medication Information

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