Asendin
® (
amoxapine) is a prescription medication that is used to treat
depression (also known as major depression or clinical depression). It is especially useful for treating people with depression who also have
anxiety or agitation and people with psychotic depression (depression with hallucinations, delusions, or other psychotic features).
(Click Asendin Uses for more information on what Asendin is used for, including possible off-label uses.)
Asendin was originally made by Lederle Laboratories, but it is no longer being manufactured.
Generic Asendin is still available and is made by Watson Pharmaceuticals.
Asendin belongs to a class of medications called
tricyclic antidepressants, although it is sometimes classified as a "tetracyclic" antidepressant, due to its chemical structure. It is not entirely clear how Asendin works. It does affect several chemicals in the brain, including serotonin and norepinephrine. It is thought that perhaps Asendin allows these chemicals to stay in the brain longer, which can help with depression symptoms. Asendin also blocks dopamine receptors, which is why it is especially useful for psychotic depression.
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