Celexa Drug Interactions

Fentanyl
Combining Celexa with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Intravenous Methylene Blue
Taking Celexa with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
   
Ketoconazole (Nizoral)
Taking ketoconazole with Celexa may decrease the level of ketoconazole in your blood, perhaps making it less effective. Your healthcare provider may need to increase your ketoconazole dose.
 
Linezolid (Zyvox)
Taking Celexa with a linezolid can cause a group of symptoms called serotonin syndrome. These symptoms include confusion, hallucinations, fast heartbeat, feeling faint, fever, sweating, muscle spasm, difficulty walking, and diarrhea. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
 
Lithium (Eskalith, Lithobid)
Taking Celexa with lithium can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Medications That Cause QT Prolongation
Celexa (especially at higher doses) can sometimes cause a certain change in the heart rhythm known as QT prolongation. QT prolongation can lead to a very serious, potentially fatal arrhythmia. Combining Celexa with other medications that can also cause QT prolongation increases the risk of serious problems. Check with your healthcare provider before combining such medications.
  
Metoprolol (Lopressor, Toprol XL)
Celexa can increase the level of metoprolol in your blood, perhaps increasing your risk of side effects. Your healthcare provider may need to adjust your dose of metoprolol.
 
Miscellaneous Antidepressants
Combining Celexa with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors (MAOIs)
Taking Celexa and an MAOI together can cause life-threatening side effects. Never take an MAOI and Celexa at the same time, and do not take them within two weeks of each other.
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Celexa Drug Information

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