Cymbalta^® (duloxetine hydrochloride) is licensed to treat depression, fibromyalgia, peripheral diabetic neuropathy pain, and generalized anxiety disorder. The medication works to treat depression and anxiety by increasing the levels of serotonin and norepinephrine available for the cells in the brain. It is not entirely clear as to how the medication works to treat neuropathic pain, but it is thought that it helps to block the nerve pain signals in the spinal cord or brain. Cymbalta comes in capsule form and is taken once or twice a day. The Cymbalta dosage your healthcare provider prescribes will vary depending on several factors, such as the medical condition you are being treated for and other medications you are taking. Prior to taking Cymbalta, be sure to tell your healthcare provider if you have seizures, liver disease, or bipolar disorder.