Monoamine Oxidase Inhibitors (MAOIs)
Taking
Cymbalta and an MAOI together can cause life-threatening side effects. Do not take Cymbalta if you have taken an MAOI within the past two weeks. Also, do not take an MAOI if you have taken Cymbalta within the past five days.
Pergolide (Permax)
Taking pergolide with Cymbalta can increase the level of Cymbalta in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your Cymbalta dose.
Phenothiazines
Cymbalta can increase the level of phenothiazine medications in your blood, increasing your risk of side effects. Also, taking these medications can increase your chance of drowsiness. Talk to your healthcare provider before taking these medications together.
One particular phenothiazine,
thioridazine (
Mellaril), should generally not be taken in combination with Cymbalta due to the risk of a dangerous irregular heart rhythm called QT prolongation.
Quinidine
Taking Cymbalta with quinidine can increase the level of Cymbalta in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your Cymbalta dose.
Quinine
Taking Cymbalta with quinine can increase the level of Cymbalta in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your Cymbalta dose.
Ritonavir (Norvir)
Taking Cymbalta with
ritonavir can increase the level of Cymbalta in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your Cymbalta dose.
Ropinirole (Requip)
Taking Cymbalta with
ropinirole can increase the level of Cymbalta in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your Cymbalta dose.
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