Cymbalta Drug Interactions

Lithium (Eskalith, Lithobid)
Taking Cymbalta with lithium can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Medications That Increase Bleeding Risk
Combining Cymbalta with medications that increase the risk of bleeding can further increase the bleeding risk. This could potentially lead to dangerous internal bleeding. Check with your healthcare provider before combining such medications.
  
Miscellaneous Antidepressants
Combining Cymbalta with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors (MAOIs)
Taking Cymbalta and an MAOI together can cause life-threatening side effects. Do not take Cymbalta if you have taken an MAOI within the past two weeks. Also, do not take an MAOI if you have taken Cymbalta within the past five days.
 
Pergolide (Permax)
Taking pergolide with Cymbalta can increase the level of Cymbalta in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your Cymbalta dose.
 
Phenothiazines
Cymbalta can increase the level of phenothiazine medications in your blood, increasing your risk of side effects. Also, taking these medications can increase your chance of drowsiness. Talk to your healthcare provider before taking these medications together.
 
One particular phenothiazine, thioridazine (Mellaril), should generally not be taken in combination with Cymbalta due to the risk of a dangerous irregular heart rhythm called QT prolongation.
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