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Cymbalta Drug Interactions

SSRI or SNRI Antidepressants
Taking Cymbalta with other SSRI or SNRI antidepressants can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these depression medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
St. John's Wort
Taking Cymbalta with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Terbinafine (Lamisil)
Taking Cymbalta with terbinafine can increase the level of Cymbalta in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your Cymbalta dose.
 
Tramadol (Ultram, Ultracet)
Taking Cymbalta with a tramadol can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Tricyclic Antidepressants
Taking Cymbalta with tricyclic antidepressants can increase the level of tricyclic antidepressants in your blood. Your healthcare provider may need to reduce your dose of the tricyclic antidepressant.
 
Triptans
Taking Cymbalta with a triptan can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
(Cymbalta Drug Interactions Continued: Page 5)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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