Cymbalta Drug Interactions

If alcohol, certain antidepressants, or other medications are taken together with Cymbalta, interactions may occur. When a Cymbalta drug interaction occurs, the levels of Cymbalta and other medications in your blood can increase, potentially increasing your risk of side effects. Some of these drug interactions can also increase your risk of a dangerous arrhythmia called QT prolongation or a dangerous condition called serotonin syndrome, among other things.

Cymbalta Drug Interactions: An Introduction

Cymbalta® (duloxetine hydrochloride) can potentially interact with a number of medicines. Some of the medicines that can lead to Cymbalta interactions include:
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
  • Monoamine oxidase inhibitors (MAOIs), including:



  • Pergolide (Permax®)
  • Phenothiazine medications, including:








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Cymbalta Medication

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