Most people tolerate this medicine well, but for some people taking Cymbalta, weight change may occur as a side effect. Some people have reported weight gain, while others have reported weight loss with this
antidepressant.
In clinical studies, up to 2 percent of people taking Cymbalta for fibromyalgia experienced weight gain. For the other uses of Cymbalta, weight gain was reported as a frequent side effect, although the exact percentage was not reported.
Other studies have shown that up to 11 percent of people taking Cymbalta reported a loss of appetite, and up to 2 percent of people reported weight loss. On average, people lost about one to three pounds while taking this medication, although it is possible for people to lose large amounts of weight while taking it.
