If you have fibromyalgia, depression, neuropathic pain, or generalized anxiety disorder, a healthcare provider may prescribe Cymbalta^® (duloxetine hydrochloride). Cymbalta is a type of serotonin-norepinephrine reuptake inhibitor, or SNRI for short, that works by affecting certain brain chemicals (serotonin and norepinephrine). Before your healthcare provider prescribes Cymbalta, he or she will consider several factors, including the medical condition being treated, other medical conditions you have, and other medications you may be taking.