Deplin Drug Interactions
Deplin Drug Interactions ExplainedThe following sections explain in detail the potentially negative interactions that can occur when Deplin is combined with any of the drugs listed above.
Bile Acid Sequestrant Medications
Bile acid sequestrant medications may decrease the absorption of Deplin into the bloodstream, possibly making it less effective. Talk to your healthcare provider before taking these medications together. Taking Deplin one hour before or four to six hours after taking a bile acid sequestrant medicine may decrease the risk for this reaction.
Certain Anti-Seizure Medications
Deplin can decrease blood levels of certain anti-seizure medications (sometimes called anti-epileptics), possibly increasing the risk for seizures. In addition, some anti-seizure medications may decrease folic acid levels. Because Deplin contains a form of folic acid, this could make Deplin less effective.
Talk to your healthcare provider before taking Deplin with an anti-seizure medicine. Your healthcare provider may need to monitor you more closely, and adjust the dose of your seizure medicine if necessary.
Deplin may decrease the effectiveness of pyrimethamine when used to treat parasitic infections. If you take Deplin with pyrimethamine, your healthcare provider may need to monitor you more closely to make sure your infection is healing.
Sulfasalazine may decrease the amount of Deplin absorbed into the bloodstream, potentially decreasing its effectiveness. Talk to your healthcare provider before taking these medicines together. Taking Deplin one hour before or four hours after sulfasalazine may decrease the risk for this interaction.