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Causes of Depression

Scientists know that depression is linked to certain chemical imbalances in the brain, but they still do not know the cause or causes of depression. However, some factors that seem to increase a person's risk of developing depression include a history of substance abuse, a family history of depression, and stress. While MRI scans show differences in the brains of people who have depression versus those who do not have depression, these images do not yet reveal why the depression has occurred.

 

Causes of Depression: An Overview

Despite intensive research, depression scientists still do not know the cause or causes of depression. They do believe that that the onset of depression is frequently caused by a combination of genetic, psychological, and environmental factors. In other words, there is no one cause of depression.
 
Depression research scientists also know that imbalances in brain chemicals known as neurotransmitters seem to be linked to depression. These brain chemicals include serotonin, norepinephrine, and dopamine. What is not known is whether these chemical imbalances are a result or a cause of depression.
  

Are Risk Factors the Same as Causes of Depression?

While scientists are still searching for depression causes, they do know a number of factors that increase a person's chances of developing depression. These are known as depression risk factors. Risk factors are not the same as causes of depression. While they do increase the chances of developing depression, they do not guarantee that a person will develop depression.
 
Some risk factors for depression include:

 

  • A family history of depression
  • Certain medications
  • A history of substance abuse
  • Certain medical illnesses
  • Hormonal factors
  • Stress.

 

(Click Risk Factors For Depression to learn more detail about each of these risk factors.)

 

(Causes of Depression Continued: Page 2)
Written by/reviewed by: Arthur Schoenstadt, MD
Last reviewed by: Arthur Schoenstadt, MD