If you have five or more symptoms of depression for two weeks or longer, you could have clinical depression and should see your healthcare provider for help. Some of these symptoms can include restlessness and irritability; feelings of worthlessness or guilt; and persistent physical symptoms that do not respond to treatment. Because there is no one specific test that can be used for diagnosing depression, your healthcare provider will begin by asking a number of questions, and will then perform a physical exam, looking for signs of conditions known to cause depression. Possible treatment options include medications and psychotherapy.