You should also be sure to tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Desipramine belongs to a class of medications called tricyclic antidepressants. It is not entirely clear how it works. However, it is known that the medication affects several chemicals in the brain, including serotonin and norepinephrine. It is thought that perhaps desipramine allows these chemical to stay in the brain longer, which can help with depression symptoms.