What Should I Tell My Healthcare Provider?You should talk with your healthcare provider prior to taking this drug if you have:
- Bipolar disorder (also known as manic depression) or a family history of bipolar disorder
- A history of suicide attempts or suicidal thoughts
- Severe anxiety or agitation
- A recent history of a heart attack
- Heart problems, including heart disease
- Hyperthyroidism (overactive thyroid)
- Seizures or epilepsy
- Bladder problems or difficulty passing urine
- An enlarged prostate (also known as benign prostatic hyperplasia or BPH)
- Any allergies, including allergies to foods, dyes, or preservatives.
Also let your healthcare provider know if you:
- Are pregnant or thinking of becoming pregnant (see Desipramine and Pregnancy)
- Are breastfeeding (see Desipramine and Breastfeeding)
- Drink alcohol regularly.
You should also be sure to tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Desipramine for more information on this topic, including information on who should not take this medication.)
Desipramine belongs to a class of medications called tricyclic antidepressants. It is not entirely clear how it works. However, it is known that the medication affects several chemicals in the brain, including serotonin and norepinephrine. It is thought that perhaps desipramine allows these chemical to stay in the brain longer, which can help with depression symptoms.