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Desipramine Withdrawal

Desipramine hydrochloride (Norpramin®) and other antidepressants are known to cause withdrawal symptoms in people who quickly stop taking their medicine.
 

Desipramine Withdrawal Symptoms

Desipramine withdrawal symptoms can include, but are not limited to:
 
  • Nausea
  • Headaches
  • Malaise (a general ill feeling).
     
In most people, these desipramine withdrawal symptoms improve with time, without the need for any treatment.
 

Limiting Desipramine Withdrawal

If you are going to be taken off of desipramine, your healthcare provider may decide to wean you off slowly to minimize the risks of developing withdrawals from desipramine.
 If withdrawal symptoms do occur, your healthcare provider may return you to your previous desipramine dosage and then wean you off even more slowly.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;