Drug Interactions With Desipramine

The following sections explain in detail the potentially negative interactions that can occur when desipramine is combined with any of the drugs listed above.

 

Desipramine may enhance the effects of alcohol. This can lead to an increased risk of suicidal thoughts and other desipramine overdose symptoms. Make sure to talk with your healthcare provider about drinking alcohol while taking desipramine.

 

Taking desipramine with anticholinergic medications may cause increased side effects. Talk with your healthcare provider before using these medications together, as your dosages may need to be reduced. Since some of these types of drugs are found in over-the-counter medicines, you should not treat yourself for the common cold, a cough, or allergies without first talking with your healthcare provider.

 

Taking desipramine with arrhythmia medications can increase your risk of a dangerous arrhythmia called QT prolongation. Also, certain arrhythmia medications can increase the level of desipramine in your blood, increasing your risk of side effects. Talk with your healthcare provider before taking these medications together.

 

Taking desipramine with barbiturates can increase the risk of side effects of both desipramine and barbiturates (such as drowsiness or dizziness). Your healthcare provider may need to adjust your doses of these medications if you are taking them together.

 

Taking desipramine with benzodiazepines can increase your risk of side effects, such as drowsiness. Talk with your healthcare provider before taking these medications together.