Effexor Drug Interactions

Fentanyl
Combining Effexor with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Haloperidol (Haldol)
Taking Effexor with haloperidol can increase the level of haloperidol in your blood, raising your risk of side effects. If you are taking these medicines together, your healthcare provider may need to decrease your haloperidol dosage.
 
Indinavir (Crixivan)
Taking Effexor with indinavir may decrease the level of indinavir in your blood, perhaps making it less effective. If you are taking these medicines together, your healthcare provider may need to increase your dose of indinavir.
 
Intravenous Methylene Blue
Taking Effexor with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Ketoconazole (Nizoral)
Taking Effexor with ketoconazole may increase the level of Effexor in your blood, increasing your risk of side effects. If you are taking these medicines together, your healthcare provider may need to decrease your Effexor dosage.
 
Linezolid (Zyvox)
Taking Effexor with linezolid can cause a group of symptoms called serotonin syndrome. These symptoms can include confusion, hallucinations, fast heartbeat, feeling faint, fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
 
Lithium (Eskalith, Lithobid)
Taking Effexor with lithium can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Miscellaneous Antidepressants
Combining Effexor with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors (MAOIs)
Taking Effexor and an MAOI together can cause life-threatening side effects. Do not take Effexor if you have taken an MAOI within the past two weeks. Also, do not take an MAOI if you have taken Effexor within the past seven days.
 
SSRI or SNRI Antidepressants
Taking Effexor with other SSRI or SNRI antidepressants can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these depression medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
St. John's Wort
Taking Effexor with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Tramadol (Rybix ODT, Ryzolt, Ultram, Ultram ER) or Tramadol and Acetaminophen (Ultracet)
Taking Effexor with tramadol can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Tricyclic Antidepressants
Taking Effexor with tricyclic antidepressants can increase the level of tricyclic antidepressants in your blood. If you are taking these medicines together, your healthcare provider may need to reduce your dose of the tricyclic antidepressant.
 
Triptans
Taking Effexor with a triptan can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Tryptophan
Taking Effexor with tryptophan can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.

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Effexor Medicine

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