Fetzima Drug Interactions
Fetzima Drug Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when any of the drugs mentioned above are combined with Fetzima.
Taking Fetzima in combination with alcohol could cause the drug to be released into your blood too quickly, potentially increasing your risk for side effects. You should not drink alcohol during Fetzima treatment.
CYP 3A4 Inducer Medications
The liver breaks down Fetzima using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Fetzima with one of these drugs may decrease the level of Fetzima in your body, potentially making it less effective. Normally, this interaction only causes small changes in Fetzima blood levels, so it is usually not necessary to change your dose if these medications are taken together.
CYP 3A4 Inhibitor Medications
The liver breaks down Fetzima using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Fetzima with one of these drugs may increase the level of Fetzima in your body, potentially increasing your risk for side effects. In some cases, it may be necessary to reduce your Fetzima dosage so you're taking no more than 80 mg a day if you are taking it with certain CYP 3A4 inhibitors.
Fetzima can cause low blood sodium levels (known medically as hyponatremia). Taking it with a diuretic may increase your risk for this side effect. Talk to your healthcare provider before taking these medications together.
Medications That Thin the Blood
Taking Fetzima with medications that increase the risk for bleeding can further increase your risk for dangerous internal bleeding. Talk to your healthcare provider before taking these medications together. Contact your healthcare provider if you develop any signs of bleeding while taking Fetzima, including:
- Abdominal (stomach) pain
- Black, tarry stools
- Vomit that looks like coffee grounds.
Monoamine Oxidase Inhibitors
Taking an MAOI with Fetzima can cause a life-threatening side effect known as serotonin syndrome. Serotonin syndrome can lead to a variety of serious symptoms, such as:
- A fast heartbeat
- Muscle spasms
- Seizures (see Fetzima Warnings and Precautions).
You should not take Fetzima if you have taken an MAOI within the past 14 days. You should also wait at least seven days after taking your last Fetzima dose before taking an MAOI.
Other Medications That Affect Serotonin
Taking Fetzima with other medications that increase serotonin levels could cause a rare but life-threatening reaction known as serotonin syndrome. Serotonin syndrome can lead to a variety of serious symptoms. Talk to your healthcare provider before taking Fetzima with other drugs that affect serotonin.