Fetzima Drug Interactions

When alcohol, diuretics, or medicines that thin the blood are taken with Fetzima, interactions may occur. When a drug interaction occurs, the levels of the medication in your blood can increase and side effects, such as hallucinations, a fast heartbeat, and seizures, may occur. The effectiveness of the medicines may also be decreased.

An Overview of Interactions With Fetzima

• Alcohol
• CYP 3A4 inducer medications, such as:
  • Aminoglutethimide (Cytadren^®)
  • Bosentan (Tracleer^®)
  • Carbamazepine (Carbatrol^®, Epitol^®, Equetro^®, Tegretol^®)
  • Dexamethasone (Decadron^®, Dexpak^®, Maxidex^®)
  • Efavirenz (Sustiva^®)
  • Efavirenz, emtricitabine, and tenofovir (Atripla^®)
  • Etravirine (Intelence™)
  • Fosphenytoin (Cerebyx^®)
  • Nafcillin
  • Nevirapine (Viramune^®)
  • Oxcarbazepine (Trileptal^®)
  • Pentobarbital (Nembutal^®)
  • Phenobarbital (Luminal^®)
  • Phenytoin (Dilantin^®, Phenytek^®)
  • Primidone (Mysoline^®)
  • Rifabutin (Mycobutin^®)
  • Rifampin (Rifadin^®)
  • Rifapentine (Priftin^®)
  • St. John's wort

• CYP 3A4 inhibitor medications, such as:
  • Amprenavir (Agenerase^®)
  • Aprepitant (Emend^®)
  • Atazanavir (Reyataz^®)
  • Clarithromycin (Biaxin^®)
  • Conivaptan (Vaprisol^®)
  • Darunavir (Prezista^®)
  • Delavirdine (Rescriptor^®)
  • Deferasirox (Exjade^®)
  • Diltiazem (Cardizem^®, Cardizem CD^®, Cardizem LA^®, Cartia XT^®, Dilacor XR^®, Dilt-CD^®, Diltia XT^®, Dilt-XR^®, Taztia XT^®, Tiazac^®)
  • Erythromycin
  • Fosamprenavir (Lexiva^®)
  • Imatinib (Gleevec^®)
  • Indinavir (Crixivan^®)
  • Isoniazid
  • Itraconazole (Sporanox^®)
  • Ketoconazole (Nizoral^®)
  • Lopinavir and ritonavir (Kaletra^®)
  • Miconazole
  • Nefazodone (Serzone^®)
  • Nelfinavir (Viracept^®)
  • Nicardipine (Cardene^®)
  • Posaconazole (Noxafil^®)
  • Quinidine
  • Ritonavir (Norvir^®)
  • Saquinavir (Fortovase^®, Invirase^®)
  • Telithromycin (Ketek^®)
  • Verapamil (Calan^®, Calan SR^®, Covera-HS^®, Isoptin SR^®, Verelan^®, Verelan PM^®)
  • Voriconazole (Vfend^®)

• Diuretics ("water pills"), such as:
  • Amiloride (Midamor^®) or amiloride-HCTZ (Moduretic^®)
  • Bumetanide (Bumex^®)
  • Chlorothiazide (Diuril^®)
  • Chlorthalidone (Thalitone^®)
  • Ethacrynic acid (Edecrin^®)
  • Furosemide (Lasix^®)
  • Hydrochlorothiazide (Esidrix^®, HydroDIURIL^®, Microzide^®, Oretic^®)
  • Metolazone (Zaroxolyn^®)
  • Spironolactone (Aldactone^®) or spironolactone-HCTZ (Aldactazide^®)
  • Torsemide (Demadex^®)
  • Triamterene (Dyrenium^®) or triamterene/HCTZ (Dyazide^®, Maxzide^®)

• Medications that "thin" the blood (such as anticoagulant and antiplatelet drugs), such as:
  • Antithrombin (ATryn^®, Thrombate III^®)
  • Apixaban (Eliquis^®)
  • Argatroban
  • Aspirin (Bayer^® and others)
  • Bivalirudin (Angiomax^®)
  • Cilostazol (Pletal^®)
  • Clopidogrel (Plavix^®)
  • Dipyridamole (Persantine^®)
  • Drotrecogin alfa (Xigris^®)
  • Eptifibatide (Integrilin^®)
  • Fondaparinux (Arixtra^®)
  • Heparin or heparin-like products, including dalteparin (Fragmin^®), enoxaparin (Lovenox^®), or tinzaparin (Innohep^®)
  • Lepirudin (Refludan^®)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
    • Celecoxib (Celebrex^®)
    • Diclofenac (Cambia™, Cataflam^®, Flector^®, Pennsaid^®, Solaraze^® Gel, Voltaren^®, Voltaren^® Gel, Voltaren^®-XR, Voltaren Ophthalmic^®, Zipsor™)
    • Etodolac (Lodine^®, Lodine^® XL)
    • Ibuprofen (Motrin^®, Advil^®, Nuprin^®)
    • Indomethacin (Indocin^®, Indocin SR^®)
    • Ketoprofen (Orudis^®, Actron^®, Oruvail^®)
    • Ketorolac (Toradol^®)
    • Meloxicam (Mobic^®)
    • Nabumetone (Relafen^®)
    • Naproxen (Naprosyn^®) or naproxen sodium (Aleve^®, Anaprox^®, Naprelan^®)
    • Oxaprozin (Daypro^®)
    • Piroxicam (Feldene^®)
    • Others (see List of NSAIDs for a more complete list of these drugs)
  • Pentoxifylline (Trental^®)
  • Prasugrel (Effient^®)
  • Rivaroxaban (Xarelto^®)
  • Thrombolytics, such as:
    • Alteplase (Activase^®)
    • Reteplase (Retavase^®)
    • Streptokinase (Streptase^®)
    • Tenecteplase (TNKase^®)
  • Ticagrelor (Brilinta^®)
  • Ticlopidine (Ticlid^®)
  • Tirofiban (Aggrastat^®)
  • Warfarin (Coumadin^®, Jantoven^®)

• Monoamine oxidase inhibitors (MAOIs), such as:
  • Isocarboxazid (Marplan^®)
  • Phenelzine (Nardil^®)
  • Rasagiline (Azilect^®)
  • Selegiline (Eldepryl^®, Emsam^®, Zelapar^®)
  • Tranylcypromine (Parnate^®)

• Other medications that affect serotonin levels, such as:
  • Amphetamines or amphetamine-like medications, such as:
    • Benzphetamine (Didrex^®)
    • Dextroamphetamine (Dexedrine^®)
    • Dextroamphetamine and amphetamine (Adderall^®)
    • Dextroamphetamine-amphetamine extended release (Adderall XR^®)
    • Lisdexamfetamine (Vyvanse^®)
    • Methamphetamine (Desoxyn^®)
    • Phendimetrazine (Bontril^®)
    • Phentermine (Adipex-P^®)
       
  • Atomoxetine (Strattera^®)
  • Buspirone (BuSpar^®)
  • Fentanyl (Abstral^®, Actiq^®, Duragesic^®, Fentora^®, Lazanda^®, Onsolis^®, Subsys^®)
  • Lithium (Eskalith^®, Eskalith CR^®, Lithobid^®)
  • Linezolid (Zyvox^®)
  • Intravenous methylene blue
  • Other antidepressants
  • Triptans, such as:
    • Almotriptan (Axert^®)
    • Eletriptan (Relpax^®)
    • Frovatriptan (Frova^®)
    • Naratriptan (Amerge^®)
    • Rizatriptan (Maxalt^®)
    • Sumatriptan (Alsuma™, Imitrex^®, Sumavel^®) or sumatriptan/naproxen sodium (Treximet^®)
    • Zolmitriptan (Zomig^®)
       
  •  St. John's wort
  • Tramadol (Rybix™ ODT, Ryzolt^®, Ultram^®, Ultram^® ER) or tramadol/acetaminophen (Ultracet^®) 
  • Tryptophan.