Does Forfivo XL Cause Seizures?
Who Is Most at Risk for Seizures With Forfivo XL?
Some people may have a higher risk for
seizures due to Forfivo XL. This includes people who have:
Also, people taking certain medications may have an increased risk for seizures
(see Forfivo XL Drug Interactions). Stopping alcohol or sedative medications suddenly also increases the risk.
No studies have been done to formally look at the risk for seizures in people taking Forfivo XL, although studies in mice suggest that
bupropion XL (the active ingredient in Forfivo XL) may be less likely to cause seizures than bupropion hydrochloride (the active ingredient in
Wellbutrin®,
Wellbutrin SR®,
Wellbutrin XL®, and
Zyban®). Therefore, it is assumed that the risk for seizures with Forfivo XL in humans is probably similar (or perhaps smaller) than that of the bupropion hydrochloride products.
Based on information from the bupropion hydrochloride products, seizures occur in 0.4 percent of people taking 300 to 450 mg of bupropion hydrochloride a day (the standard dosage for Forfivo XL is 450 mg a day). The risk for seizures increases significantly at higher doses. For example, increasing the dosage from 450 mg to 600 mg resulted in a 10-fold increase in seizure risk. Seizures were more likely to occur when people first started taking bupropion. Also, certain types of people are more likely to have seizures.
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