Drug Interactions With Imipramine Pamoate

The following sections explain in detail the potentially negative interactions that can occur when imipramine is combined with any of the drugs listed above.

 

Imipramine may enhance the effects of alcohol. This can lead to an increased risk of suicidal thoughts and other imipramine overdose symptoms. Make sure to talk with your healthcare provider about drinking alcohol while taking imipramine.

 

Taking imipramine with anticholinergic medications may cause increased side effects. Talk with your healthcare provider before using these medications together, as your dosages may need to be reduced. Since some of these types of medicines are found in over-the-counter drugs, do not treat yourself for the common cold, a cough, or allergies without first talking with your healthcare provider.

 

Taking imipramine with arrhythmia medications can increase your risk of a dangerous arrhythmia called QT prolongation. Also, certain arrhythmia medications can raise the level of imipramine in your blood, increasing your risk of side effects. Talk with your healthcare provider before taking these medications together.

 

Taking imipramine with barbiturates can increase the risk of side effects of both imipramine and barbiturates (such as drowsiness or dizziness). Also, barbiturates may decrease the level of imipramine in your blood, perhaps making it less effective. If you are taking imipramine with barbiturates, your healthcare provider may need to adjust your doses of these medications.

 

Imipramine can make certain blood pressure medications, such as clonidine (Catapres^®), less effective. Also, taking imipramine with high blood pressure medications may increase your chances of developing low blood pressure (hypotension). Talk with your healthcare provider before taking imipramine with a blood pressure medication.