Drug Interactions With Imipramine Pamoate

Barbiturates
Taking imipramine with barbiturates can increase the risk of side effects of both imipramine and barbiturates (such as drowsiness or dizziness). Also, barbiturates may decrease the level of imipramine in your blood, perhaps making it less effective. If you are taking imipramine with barbiturates, your healthcare provider may need to adjust your doses of these medications.
 
Blood Pressure Medications
Imipramine can make certain blood pressure medications, such as clonidine (Catapres®), less effective. Also, taking imipramine with high blood pressure medications may increase your chances of developing low blood pressure (hypotension). Talk with your healthcare provider before taking imipramine with a blood pressure medication.
 
Buspirone (BuSpar)
Because combining imipramine pamoate with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
 
Cimetidine (Tagamet)
Taking imipramine with cimetidine can raise the level of imipramine in your blood, increasing your chances of side effects. Your healthcare provider may need to adjust your doses of these medications.
 
Fentanyl
Combining imipramine pamoate with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Intravenous Methylene Blue
Taking imipramine pamoate with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Lithium
Combining imipramine pamoate with lithium may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
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