Drug Interactions With Imipramine Pamoate
Linezolid (Zyvox)Taking imipramine pamoate with linezolid can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
Methylphenidate may increase the level of imipramine in your blood. If you are taking methylphenidate along with imipramine, your healthcare provider may need to adjust your imipramine dosage -- especially if you are starting or stopping methylphenidate.
Monoamine Oxidase Inhibitors (MAOIs)
Taking imipramine with MAOIs can increase your chances of developing dangerous side effects. Do not take imipramine if you have taken an MAOI within the past two weeks.
Taking imipramine with phenothiazine medications can raise the level of imipramine in your blood, increasing your risk of side effects. Also, combining imipramine with certain phenothiazines can increase your risk of a dangerous irregular heart rhythm called QT prolongation. Talk with your healthcare provider before taking these medications together.
Phenytoin may decrease the level of imipramine in your blood. If you are taking phenytoin along with imipramine, your healthcare provider may need to adjust your imipramine dose -- especially if you are starting or stopping phenytoin.
Taking imipramine with pressor medications can increase your risk of side effects. If you are taking imipramine with a pressor medication, your healthcare provider may need to adjust your doses of these medications.
SSRI or SNRI Medications