Imipramine Pamoate Dosing

For most people who are taking imipramine pamoate, dosing starts at 75 mg once a day. If needed, your daily dosage can be increased up to 300 mg once a day. Since it is generally recommended that teenagers and elderly people start with a lower dosage, healthcare providers may prescribe imipramine hydrochloride (which is available in lower strengths) instead of imipramine pamoate for these age groups. In order for the medicine to work properly, you must take it as prescribed.

Imipramine Pamoate Dosage: An Overview

The dose of imipramine pamoate (Tofranil PM®) that your healthcare provider prescribes will vary depending on a number of factors, including:
  • Your age
  • Other medical conditions you may have
  • Other medications you may be currently taking.
As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Imipramine Pamoate Dosing for Depression

The recommended starting imipramine dose for depression treatment is 75 mg once a day at bedtime. If needed, your healthcare provider may increase your dose up to 300 mg total per day. Although most people take imipramine once a day, your healthcare provider may recommend taking it more often, especially if you are taking a higher dose.
For the treatment of teenage depression or depression in elderly people, lower doses are recommended. However, because the lowest available strength of imipramine pamoate is 75 mg, it is recommended that teens or elderly people start with imipramine hydrochloride (not imipramine pamoate), which comes in lower strengths.
If you do not take your imipramine as scheduled, take your missed dose as soon as you remember. However, if you usually take your dose at night, you may not want to make up the missed dose, due to the risk of drowsiness if imipramine is taken during the day. Also, if it almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose of imipramine.
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Imipramine Pamoate (Tofranil PM)

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