Imipramine can potentially interact with a number of other medications.
(Click Drug Interactions With Imipramine Pamoate for more information about imipramine and other medications.)
You should talk with your healthcare provider prior to taking imipramine if you have:
- Bipolar disorder (also known as manic depression) or a family history of bipolar disorder
- A history of suicide attempts or suicidal thoughts
- Severe anxiety or agitation
- A recent history of a heart attack
- Heart problems, including heart disease
- Hyperthyroidism (overactive thyroid)
- Seizures or epilepsy
- An upcoming surgery
- Bladder problems or difficulty passing urine
- An enlarged prostate (also known as benign prostatic hyperplasia or BPH)
- Any allergies, including allergies to foods, dyes, or preservatives.
Also let your healthcare provider know if you:
- Are pregnant or thinking of becoming pregnant (see Imipramine and Pregnancy)
- Are breastfeeding (see Imipramine and Breastfeeding)
- Drink alcohol regularly.
You should also be sure to tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Imipramine Pamoate for more information on this topic, including information on who should not take imipramine.)