Imipramine Pamoate Side Effects

Some common side effects of imipramine pamoate include drowsiness, weight loss or weight gain, and difficulty urinating. In most cases, side effects are mild and either require no treatment or can easily be treated. Certain side effects, however, are more serious and should be reported to your healthcare provider. These serious imipramine pamoate side effects can include changes in heart rhythm, hostility or aggressiveness, and seizures.

An Introduction to Imipramine Pamoate Side Effects

As with any medicine, side effects are possible with imipramine pamoate (Tofranil PM®). However, not everyone who takes the antidepressant will experience side effects. In fact, most people tolerate it well. If people do develop imipramine pamoate side effects, in many cases, they are minor, meaning they require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with imipramine pamoate. Your healthcare provider can discuss a more complete list of imipramine pamoate side effects with you.)

Side Effects of Imipramine Pamoate to Report

There are a number of less common but potentially serious side effects with imipramine that you should report to your healthcare provider. These side effects include but are not limited to:
  • A heart attack or stroke
  • Changes in heart rhythm (arrhythmia)
  • A fast heart rate (tachycardia) or feelings of a rapidly or forcefully beating heart (palpitations)
  • Seizures
  • Confusion, delusions, or hallucinations
  • Signs of an allergic reaction, including unexplained rash, hives, itching, unexplained swelling, wheezing, or difficulty breathing or swallowing.
  • Any breast changes, including breast enlargement or breast discharge
  • Swelling of the testicles
  • Yellowing of the eyes or skin (jaundice)
  • Suicidal thoughts or behavior (see Imipramine and Suicide)
  • Hostility or aggressiveness
  • Engaging in unusual or dangerous activities
  • Restlessness or an inability to sit still
  • Extreme elation or feelings of happiness that may switch back and forth with a depressed or sad mood
  • Other unusual changes in behavior
  • Difficulty sleeping
  • Anxiety, agitation, or panic attacks
  • A fever or sore throat (or any other signs of an infection).
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Imipramine Pamoate (Tofranil PM)

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