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Imipramine Pamoate

If you suffer from depression, your healthcare provider may prescribe imipramine. The prescription medicine, which is part of a class of drugs known as tricyclic antidepressants, is approved for the treatment of depression in adults. By affecting certain chemicals in the brain (norepinephrine and serotonin), the antidepressant can help improve the symptoms of depression. Imipramine comes in capsule form and is generally taken one or two times a day. Drowsiness, dizziness, and difficulty urinating are among the most common side effects of imipramine.

 

What Is Imipramine Pamoate?

Imipramine pamoate (Tofranil PM®) is a prescription medication used to treat depression (also known as major depression or clinical depression) in adults. It is part of a class of drugs known as tricyclic antidepressants. Imipramine pamoate is different from imipramine hydrochloride (Tofranil®), a similar medication that is approved to treat bedwetting in children in addition to depression in adults (see Imipramine for information about the differences between imipramine hydrochloride and imipramine pamoate).
 
(Click What Is Imipramine Pamoate Used For? for more information on imipramine uses, including possible off-label uses.)
 

Who Makes Imipramine Pamoate?

Imipramine is made by Mallinckrodt Pharmaceuticals. Generic imipramine is also made by Mallinckrodt Pharmaceuticals.
 

How Does Imipramine Pamoate Work?

Imipramine belongs to a class of medications called tricyclic
 antidepressants. It is not entirely clear how imipramine works. However, it is known that imipramine affects several chemicals in the brain, including serotonin and norepinephrine. It is thought that perhaps imipramine allows these chemicals to stay in the brain longer, which can help with depression symptoms.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;