Precautions and Warnings With Imipramine Pamoate

Some Precautions and Warnings With Imipramine Pamoate

Some imipramine precautions and warnings to be aware of include:
  • Antidepressants (including imipramine) may increase the risk of suicidal thinking or behavior in children, teenagers, and adults (see Antidepressants and Suicide for more information). Therefore, if you notice any changes in symptoms or new symptoms while taking imipramine, you should talk with your healthcare provider immediately. Some of these symptoms may include: anxiety, hostility, agitation, panic, restlessness, hallucinations, extreme hyperactivity, and suicidal thinking or behavior (see Imipramine and Suicide for more information).
  • Before prescribing imipramine for depression, your healthcare provider should make sure that you do not have bipolar disorder (instead of depression). Sometimes, the symptoms of bipolar disorder and depression are very similar, and imipramine can cause problems in people with bipolar disorder.
  • Imipramine may cause a worsening of schizophrenia. Discuss this with your healthcare provider before taking imipramine.
  • For people taking imipramine, caution should be used when driving, operating heavy machinery, or performing other tasks that require concentration, especially when first starting imipramine or when switching dosages. This is because imipramine may affect a person's mental or physical ability to perform these tasks. Make sure to understand how imipramine affects you before performing any tasks that require mental or physical concentration.
  • Imipramine can interact with certain other medications (see Drug Interactions With Imipramine Pamoate).
  • Imipramine may enhance the effects of alcohol, barbiturates, and other medicines that affect the brain. This can lead to an increased risk of drowsiness, dizziness, suicidal thoughts, and other imipramine overdose symptoms. Make sure to talk with your healthcare provider about drinking alcohol while taking imipramine.
  • Imipramine may not be safe for use during pregnancy. Talk with your healthcare provider about the benefits and risks of using the medication during pregnancy (see Imipramine and Pregnancy for more information).
  • Imipramine passes through breast milk and may cause harm to your baby. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about what makes most sense for your particular situation (see Imipramine and Breastfeeding).
  • If you have a history of seizures, bladder problems, or glaucoma, you should use special care when taking imipramine. Imipramine can make these conditions worse.
  • Talk with your healthcare provider before taking imipramine if you have any heart problems, as the drug can affect the heart and its electrical system. Your healthcare provider should check your heart rhythm using an electrocardiogram (EKG or ECG) if you are taking high doses of imipramine.
  • Talk with your healthcare provider before taking imipramine if you have hyperthyroidism (overactive thyroid) or take thyroid medication.
  • Imipramine can decrease your level of white blood cells, which can increase your risk of infections. Let your healthcare provider know if you have signs of an infection (such as a fever or sore throat) while taking imipramine.
  • Taking imipramine while receiving electroshock or electroconvulsive therapy (ECT) can increase your risk of side effects. Talk with your healthcare provider about these risks.
  • Imipramine may cause a dry mouth. Sucking on hard candy, chewing gum, or melting bits of ice in your mouth can provide relief from dry mouth.
  • Elderly people appear to be more sensitive to imipramine, which can increase their risk of side effects (such as delirium and confusion). In these particular situations, the healthcare provider will start people on lower doses and monitor them more closely.
  • If you have diabetes, you should make sure to check your blood sugar levels more often when starting imipramine or changing dosages. There have been reports of increased or decreased blood sugar levels in people who take imipramine.
  • During treatment with imipramine, do not treat yourself for the common cold, a cough, or allergies without first talking with your healthcare provider. Some of these medicines can increase the risk of developing imipramine side effects.
  • Do not stop taking imipramine without first discussing it with your healthcare provider. Stopping the medicine abruptly may increase the risk of withdrawal symptoms (see Imipramine Withdrawal).
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