What Is Imipramine Pamoate Used For?

How Imipramine Pamoate Works

Imipramine belongs to a class of medications called tricyclic antidepressants. It is not entirely clear how imipramine works. However, it is known that imipramine affects several chemicals in the brain, including serotonin and norepinephrine. It is thought that perhaps imipramine allows these chemicals to stay in the brain longer, which can help with depression symptoms.

Is Imipramine Pamoate Used for Children and Teens?

Imipramine is not recommended for treating depression in people under 18 years old, as it has not been thoroughly studied for the treatment of teenage or childhood depression. Talk with your healthcare provider about using imipramine in children or teenagers.

Is Imipramine Pamoate Used for Off-Label Reasons?

On occasion, your healthcare provider may recommend imipramine for treating something other than depression. This is called an "off-label" use. At this time, there are several off-label imipramine uses. Following are some of the conditions that can be treated off-label with imipramine:
  • Chronic pain: Imipramine works best for chronic pain that is nerve-related, such as nerve pain from having shingles (including postherpetic neuralgia).
  • Anxiety disorders: Many antidepressants (including imipramine) are used to treat anxiety disorders.
  • Incontinence: Imipramine is sometimes used to treat problems associated with bladder control in adults.
  • Bedwetting: Imipramine can help children stop bedwetting.
  • Attention deficit hyperactivity disorder (ADHD): Imipramine can be used to treat ADHD, especially if other ADHD medications have not been effective or have caused side effects.
  • Fibromyalgia: Imipramine has been used to treat pain and other symptoms of fibromyalgia.
  • Migraine headaches: Imipramine can be used on a daily basis to prevent migraine headaches. It is not effective for treating a migraine headache once it starts.
  • Bulimia: Imipramine has been found to improve bulimia symptoms, including binge eating and vomiting.
  • Smoking: Imipramine is sometimes used to help people quit smoking.
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Imipramine Pamoate (Tofranil PM)

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