Drug Interactions With Isocarboxazid

Narcotics
Taking isocarboxazid with narcotics can increase your chance of side effects (such as drowsiness or low blood pressure). Isocarboxazid should not be taken with narcotics.
 
Pressors
Do not take pressors and isocarboxazid together, due to the risk of dangerous side effects (such as high blood pressure).
 
Reserpine
Do not take reserpine and isocarboxazid together, due to the risk of dangerous side effects (such as high blood pressure).
 
Sibutramine (Meridia)
You should not take sibutramine and isocarboxazid within 14 days of each other, due to the risk of dangerous side effects.
 
SSRI or SNRI Medications
Do not take SSRIs or SNRIs together with isocarboxazid, due to the risk of serious side effects. Because certain SSRIs or SNRIs can stay in your body for quite a while, make sure to ask your healthcare provider when you can start taking an SSRI or SNRI after stopping isocarboxazid (or the other way around).
 
Stimulants
Do not take stimulants and isocarboxazid together, due to the risk of dangerous side effects (such as high blood pressure).
 
Tolcapone (Tasmar)
Combining tolcapone and isocarboxazid can lead to dangerous side effects. Talk to your healthcare provider before taking these medications together.
 
Tricyclic Antidepressants
Do not take tricyclic antidepressants and isocarboxazid together, due to the risk of dangerous side effects (such as high blood pressure or seizures). You will need to wait at least one week after stopping a tricyclic antidepressant before starting isocarboxazid, and you will need to be started at a lower isocarboxazid dosage.
Healthy Pet, Healthy You

Isocarboxazid (Marplan)

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