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Drug Interactions With Isocarboxazid

Drug interactions with isocarboxazid may occur with a variety of medications. Some drugs that may interact with isocarboxazid include barbiturates, blood pressure medications, and cold or allergy medicines. Several potential drug interactions with isocarboxazid can lead to dangerous side effects, such as seizures or dangerously high blood pressure. Therefore, you should talk to your healthcare provider about potential drug interactions with isocarboxazid that may apply to you.

 

Drug Interactions With Isocarboxazid: An Introduction

 Isocarboxazid (Marplan®) can potentially interact with many medicines. Because there are so many isocarboxazid drug interactions that can be very dangerous, it is important to check with your healthcare provider before taking any medication, whether prescription or over-the-counter. Make sure to tell all your healthcare providers (including dentists and surgeons) that you are taking isocarboxazid. Some of the medicines that may lead to isocarboxazid interactions include:
 
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®) 
o Dextromethorphan (Robitussin DM® and many others)
o Naphazoline (various nasal and eye drops, such as Visine-A®)
o Oxymetazoline (various nasal and eye drops, such as Afrin®)
o Phenylephrine (Sudafed PE® and many others)
o Propylhexedrine (Benzedrex®)
o Pseudoephedrine (Sudafed® and many others) 
  • Narcotics, such as codeine, hydrocodone, morphine, and many others
  • Pressors, including:
o Dopamine
o Ephedrine
o Epinephrine (Adrenalin®, EpiPen®)
o Isometheptene (Duradrin®, Midrin®, Migquin®, Migratine®, Migrazone®, Migrin-A®)
o Levonordefrin (Carbocaine with Neo-Cobefrin®)
o Midodrine (Orvaten®, ProAmatine®)
o Norepinephrine (Levophed®)
  • Stimulants, such as:
o Dextroamphetamine (Dexedrine®, Dexedrine Spansules®)
o Phentermine (Adipex-P®, Ionamin®) 
o Amitriptyline and chlordiazepoxide (Limbitrol®)
o Amitriptyline and perphenazine (Etrafon®)
(Drug Interactions With Isocarboxazid Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;