Lexapro Drug Interactions

Lexapro and Serotonin Syndrome

Several of the known interactions with Lexapro are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.

Lexapro Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Lexapro is combined with any of the drugs listed above. 


It is not recommended that you drink alcohol while taking Lexapro. Combining alcohol and Lexapro may cause unwanted side effects (see Alcohol and Lexapro).
Taking Lexapro and aspirin together can increase your risk of stomach bleeding. Talk with your healthcare provider before taking aspirin and Lexapro together.
Buspirone (BuSpar)
Because combining Lexapro with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
Cimetidine (Tagamet)
Taking cimetidine and Lexapro together can increase the level of Lexapro in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your Lexapro dose or may suggest an alternative to cimetidine.
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Lexapro Medication

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