Lexapro Drug Interactions

Fentanyl
Combining Lexapro with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Intravenous Methylene Blue
Taking Lexapro with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Ketoconazole (Nizoral)
Taking ketoconazole with Lexapro may decrease the level of ketoconazole in your blood, perhaps making it less effective. Your healthcare provider may need to increase your ketoconazole dose.
 
Linezolid (Zyvox)
Taking Lexapro with linezolid can cause a group of symptoms called serotonin syndrome. These symptoms can include confusion, hallucinations, fast heartbeat, feeling faint, a fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of the symptoms mentioned above, as serotonin syndrome can be very dangerous.
 
Lithium (Eskalith, Lithobid)
Taking Lexapro with lithium can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Metoprolol (Lopressor, Toprol XL)
Lexapro can increase the level of metoprolol in your blood, perhaps increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to adjust your dose of metoprolol.
 
Miscellaneous Antidepressants
Combining Lexapro with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors (MAOIs)
Taking Lexapro and an MAOI together can cause life-threatening side effects. Never take an MAOI and Lexapro at the same time, and do not take them within two weeks of each other.
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Lexapro Medication

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