Lexapro Drug Interactions

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Taking Lexapro and NSAIDs together can increase your risk of stomach bleeding. Talk with your healthcare provider before taking NSAIDs and Lexapro together.
 
Pimozide (Orap)
Pimozide and Lexapro should not be taken together, as the combination may cause a dangerous irregular heart rhythm (arrhythmia) called QT prolongation.
 
SSRI or SNRI Antidepressants
Taking Lexapro with other SSRI or SNRI antidepressants can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these depression medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
St. John's Wort
Taking Lexapro with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Tramadol (Rybix ODT, Ryzolt, Ultram, Ultram ER) or Tramadol and Acetaminophen (Ultracet)
Taking Lexapro with tramadol can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Tricyclic Antidepressants
Taking Lexapro with tricyclic antidepressants can increase the level of tricyclic antidepressants in your blood. If you are taking these drugs together, your healthcare provider may need to reduce your dose of the tricyclic antidepressant.
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Lexapro Medication

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