Depression Home > Antidepressant Uses

Antidepressants are most commonly used for treating depression. However, these medications can also be used for other conditions as well. For example, newer antidepressants (such as SSRIs, SNRIs, and NDRIs) have been approved for treating conditions such as panic disorder, bulimia, and social anxiety disorder. General off-label antidepressant uses include the treatment of Tourette syndrome, autism, migraines, and premature ejaculation.

What Are Antidepressants Used For?

As would be expected, the most common use for most antidepressants is depression treatment. However, most antidepressants are approved for treating other conditions as well. These uses vary with the different types of antidepressants.
 

SSRI, SNRI, or NDRI Antidepressant Uses

Various SSRIs (selective serotonin reuptake inhibitors) have been approved for the following uses:
 
Not all SSRIs are approved for all of the uses listed above (see Comparisons of SSRI Antidepressants for more information).
 
Various SNRIs (serotonin-norepinephrine reuptake inhibitors) are approved for the following uses:
 
Not all SNRIs are approved for all of the uses listed above.
 
NDRIs (norepinephrine and dopamine reuptake inhibitors) have been approved to treat depression, seasonal affective disorder (SAD), and for use as a smoking cessation agent (to help people stop smoking). Currently, there is only one NDRI medication, bupropion, approved for use in the United States.
 
Bupropion comes in several forms (Aplenzin™, Budeprion XL®, Budeprion™ SR, Buproban®, Forfivo™ XL, Wellbutrin SR®, Wellbutrin XL®, Wellbutrin®, Zyban®). Aplenzin, Budeprion SR, Wellbutrin SR, Forfivo, and Wellbutrin are approved only for depression treatment. Budeprion XL and Wellbutrin XL are approved for treating depression and seasonal affective disorder. Zyban and Buproban are approved for smoking cessation only.
  
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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