According to the manufacturer of Aplenzin (bupropion hydrobromide), women should not use this medication while nursing. Research studies have shown that the bupropion component of the drug does pass through breast milk and may cause problems in an infant. Before using Aplenzin, breastfeeding women should ask their healthcare providers about the potential risks.
Can Breastfeeding Women Safely Take Aplenzin?
Aplenzin™ (bupropion hydrobromide) passes through breast milk in humans. The manufacturer of Aplenzin recommends that women should not take this medication while breastfeeding. Therefore, if you are nursing an infant, talk with your healthcare provider before taking this antidepressant.
What Does the Research Say?
Studies have shown that bupropion (the active ingredient in Aplenzin) passes through breast milk, probably in small amounts. There has been one reported case in which a breastfed infant experienced a seizure that might have possibly been related to bupropion usage in the mother. However, there have also been a number of other cases reported in which no problems occurred.
If your healthcare provider decides that it is okay for you to take Aplenzin while breastfeeding, make sure to watch for any changes or problems in your infant. In particular, watch for seizures, decreased appetite, irritability, or unusual fussiness. If you are at all concerned, please consult with your healthcare provider and/or your child's healthcare provider.
Talking With Your Healthcare Provider
You should talk with your healthcare provider about breastfeeding while taking Aplenzin. Each woman's situation is different, and you and your healthcare provider understand your situation best. After considering what you want and expect, as well as your current health situation, the two of you can make a shared decision that is right for you.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Aplenzin [package insert]. Bridgewater, NJ: sanofi-aventis U.S. LLC;2011 July.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed May 17, 2010.
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