Depression Home > What Is Budeprion XL Used For?

Budeprion XL Uses for Seasonal Affective Disorder

Seasonal affective disorder is depression that is related to a particular time of the year. The most common time for it to occur is during winter. Symptoms of seasonal affective disorder are the same as those for depression, except they only occur during the autumn and winter. It is thought that a lack of sunlight might be the cause of seasonal affective disorder.
Light therapy is one type of treatment available for the condition. Antidepressant medications, such as Budeprion XL, can also be used. Usually, the medication is started in the autumn, before symptoms begin, and is stopped in early spring.

How Budeprion XL Works

Budeprion XL is a norepinephrine and dopamine reuptake inhibitor, or NDRI for short. NDRIs, such as Budeprion XL, affect specific chemicals within the brain known as norepinephrine and dopamine. These are two of several chemicals used to send messages from one nerve cell to another.
As a message travels down a nerve, it causes the end of the cell to release norepinephrine or dopamine. The chemical enters the gap between the first nerve cell and the one next to it. When enough norepinephrine or dopamine reaches the second nerve cell, it activates receptors on the cell, and the message continues on its way. The first cell then quickly absorbs any norepinephrine or dopamine that remains in the gap between the cells. This is called "reuptake."
Normally, this process works without any problems. But when the levels of dopamine and norepinephrine become unbalanced, it can cause a variety of conditions, including depression and seasonal affective disorder. Budeprion XL helps to block the reuptake of norepinephrine and dopamine so that more remains in the space between the brain's nerve cells. This gives the chemicals a better chance of activating the receptors on the next nerve cell.
Currently, the only NDRI antidepressants approved for use are medications containing bupropion. Budeprion XL is the longest-acting version of bupropion, taken just once a day. Bupropion also comes in several other forms, including:


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Last reviewed by: Kristi Monson, PharmD;
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