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Celexa and Serotonin Syndrome

Several of the known interactions with Celexa are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.

Celexa Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Celexa is combined with any of the drugs listed above.
It is not recommended to drink alcohol while taking Celexa. Combining alcohol and Celexa may cause unwanted side effects (see Celexa and Alcohol).
Taking Celexa and aspirin together can increase your risk of stomach bleeding. Talk to your healthcare provider before taking aspirin and Celexa together.
Buspirone (BuSpar)
Because combining Celexa with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
CYP 2C19 Inhibitors
The body breaks down ("metabolizes") Celexa using specific liver enzymes known as CYP 2C19 enzymes. Several other drugs slow down the activity of these enzymes (these drugs are known as CYP 2C19 inhibitors) and can significantly increase the level of Celexa in the body. This may increase the risk of dangerous Celexa side effects. For people taking a CYP 2C19 inhibitor medication, the maximum recommended dosage of Celexa is 20 mg a day.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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