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Cymbalta Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Cymbalta is combined with any of the drugs listed above.
 
Alcohol
It is not recommended to drink alcohol while taking Cymbalta. Combining alcohol and Cymbalta together may cause unwanted side effects (see Cymbalta and Alcohol).
 
Certain Arrhythmia Medications
Taking Cymbalta with certain arrhythmia medications can increase the level of Cymbalta or the arrhythmia medication in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor you more closely and may need to adjust your dose of these medications.
 
Certain Fluoroquinolone Antibiotics
Taking Cymbalta with certain fluoroquinolone antibiotics can increase the level of Cymbalta in your blood, increasing your risks of side effects. Your healthcare provider may need to decrease your Cymbalta dose or may suggest a different antibiotic.
 
Delavirdine (Rescriptor)
Taking delavirdine with Cymbalta can increase the level of Cymbalta in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your Cymbalta dosage.
 
Linezolid (Zyvox)
Taking Cymbalta with a linezolid can cause a group of symptoms called serotonin syndrome. These symptoms include confusion, hallucinations, a fast heartbeat, feeling faint, fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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