Depression Home > Nardil and Pregnancy

In animal studies on Nardil and pregnancy, the medication appeared to reduce the number of offspring that survived. Since MAOIs like Nardil are usually used as a last resort for depression treatment, it may not be possible to stop taking it, because severe depression can also be harmful to the fetus. If you are taking Nardil and pregnancy occurs, your healthcare provider will weigh the benefits and risks before making a recommendation.

Nardil and Pregnancy: An Overview

Nardil® (phenelzine sulfate) may not be safe for women to take when pregnant. The medication is used to treat depression and is part of a group of medications called monoamine oxidase inhibitors (MAOIs).

Nardil and Pregnancy: What's the Risk?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. However, the FDA has not given Nardil a pregnancy risk classification, as is common with older medications, because there is very little information available about the use of Nardil during pregnancy.
In studies of Nardil in mice, the medication reduced the number of offspring that survived. Also, there have been reports of birth defects in women taking the drug, although it is not clear if the defects were caused by the medication or by something else. It is not fully known how Nardil might affect a growing fetus. However, since MAOIs (like Nardil) are usually used as a last resort in people with severe depression, it may not be possible for some pregnant women to stop taking Nardil. In fact, depression in the mother can be damaging to the baby.

Nardil and Pregnancy: Recommendations

If you are taking Nardil and pregnancy occurs, or if you are thinking about becoming pregnant while taking the drug, let your healthcare provider know. He or she will consider the benefits and risks of using Nardil during pregnancy before making a recommendation for your particular situation.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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