Depression Home > Nefazodone

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking this medication if you have:
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Nefazodone for more information on this topic, including information on who should not take nefazodone.)

How Does It Work?

It is not entirely clear how nefazodone works. There are no other medications that work exactly like it. Nefazodone acts on specific chemicals within the brain known as serotonin and norepinephrine. Serotonin and norepinephrine are chemicals used to send messages between nerves; when serotonin and norepinephrine levels become unbalanced, however, it can cause a variety of conditions, including depression. Nefazodone helps to block the reuptake of serotonin and norepinephrine so that more is available for the nerves in the brain, returning the serotonin back to its "normal" levels. However, unlike selective serotonin reuptake inhibitors (SSRIs), nefazodone may also block certain types of serotonin receptors.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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