Depression Home > Side Effects of Nefazodone

Possible side effects of nefazodone include headache, drowsiness, and heartburn. In most cases, side effects are minor and either don't require medical attention or can be treated easily. In some situations, however, nefazodone side effects may be more serious and should be reported to a healthcare provider immediately, including fast heart rate, chest palpitations, and suicidal thoughts or behavior.

Nefazodone Side Effects: An Introduction

As with any medicine, there are possible side effects with nefazodone hydrochloride (Serzone®). However, not everyone who takes the antidepressant will experience side effects. In fact, most people tolerate it well. When nefazodone side effects do occur, in most cases they are minor and either require no treatment or can be easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with nefazodone. Your healthcare provider can discuss a more complete list of nefazodone side effects with you.)

Common Side Effects of Nefazodone

Nefazodone has been studied thoroughly in clinical trials in which a group of people taking the drug have side effects documented and compared to another group not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
In these studies, the most common side effects of nefazodone included:
  • Headache -- in up to 36 percent of people
  • Dry mouth -- up to 25 percent (see Serzone and Dry Mouth)
  • Drowsiness -- up to 25 percent
  • Nausea -- up to 22 percent
  • Dizziness -- up to 17 percent
  • Constipation -- up to 14 percent
  • Weakness -- up to 11 percent
  • Insomnia -- up to 11 percent (see Serzone and Insomnia)
  • Lightheadedness -- up to 10 percent
  • Heartburn -- up to 9 percent
  • Blurred vision -- up to 9 percent
  • Infections -- up to 8 percent
  • Diarrhea -- up to 8 percent
  • Confusion -- up to 7 percent
  • Sore throat -- up to 6 percent.
Other common side effects of Nefazodone (occurring in 1 to 5 percent of people) included:
  • Impotence (known as erectile dysfunction or ED)
  • Increased appetite
  • Low blood pressure when standing or sitting up suddenly (orthostatic hypotension)
  • Memory problems or concentration problems
  • Unusual sensations, such as tingling or burning (paresthesias)
  • Flushing (redness of the skin, especially the face)
  • Flu-like symptoms (such as fever or chills)
  • Fluid retention, especially in the legs
  • Abnormal dreams
  • Coughing
  • Problems with muscle coordination
  • Shakiness (tremor)
  • Ringing of the ears (tinnitus)
  • Taste changes
  • Frequent urination or difficulty urinating
  • Urinary tract infection (bladder infection)
  • Vaginal infection or irritation
  • Neck stiffness
  • Thirst
  • Joint pain
  • Muscle tension
  • Decreased sex drive
  • Breast pain.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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