Depression Home > Best Time to Take Nortriptyline

Nortriptyline hydrochloride (Pamelor®) is a medication commonly used in the treatment of depression. It is believed to help alleviate symptoms by causing more serotonin and norepinephrine to stay in the brain, although its exact mechanism is not entirely understood.
You will take nortriptyline anywhere from one to four times a day, depending on your healthcare provider's recommendations. The usual starting dose is 25 mg, taken three or four times a day; however, dosing is calculated on an individual basis.
If the medication causes drowsiness or dizziness, you may find that the best time to take nortriptyline is right before bedtime, instead of during the day. In addition, you can take a dose with food, which might help prevent stomach upset.
The important thing to keep in mind during treatment with nortriptyline is that it can take several weeks to feel the full effects, so you should not adjust your dose without your healthcare provider's approval and supervision. Do not skip doses, and do not take more than the recommended amount.
(Click Nortriptyline Dosing for more tips on when and how to take this medication. This article also explains in detail the factors that affect a person's dose and provides typical dosages for treating depression.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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