Depression Home > Oleptro and Sexual Problems

Clinical studies have shown that sexual side effects are possible with Oleptro (trazodone ER). Sexual problems may include ejaculation problems, decreased sex drive, and impotence. If you are taking this medication and you experience sexual side effects, your healthcare provider may adjust your dosage or recommend another antidepressant medication.

Does Oleptro Cause Sexual Side Effects?

Oleptro™ (trazodone ER), like many antidepressants, is known to cause certain sexual problems. Oleptro's sexual side effects may include:
  • Ejaculation problems
  • Decreased sex drive
  • Impotence, also known as erectile dysfunction or ED
  • Orgasm problems
  • Priapism, a painful erection that does not go away.
Oleptro and Ejaculation Problems
In clinical studies, 1.5 percent of people taking Oleptro reported an "ejaculation disorder." Trazodone (the active ingredient in Oleptro) is known to cause retrograde ejaculation. Retrograde ejaculation is "backward" ejaculation, when the ejaculate goes into the bladder instead of out through the penis. Retrograde ejaculation is generally painless and is usually not a problem. Symptoms of retrograde ejaculate include absence of ejaculate and cloudy urine.
Oleptro and Low Libido
In clinical studies, up to 1.5 percent of people taking Oleptro experienced a decrease in sex drive.
Oleptro and Impotence
Impotence is often defined as a total inability to achieve an erection, an inconsistent ability to do so, or a tendency to sustain only brief erections. Ultimately, impotence is the repeated inability to get or keep an erection firm enough for sexual intercourse. In clinical studies, less than 1 percent of people taking Oleptro reported problems with impotence.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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