Depression Home > Oleptro

Available by prescription, Oleptro is a drug licensed to treat depression. Although it is not exactly known how the medication works, it is thought to balance serotonin levels in the brain and block certain serotonin receptors. This long-acting antidepressant comes in tablet form and is taken only once a day. Potential side effects may include drowsiness, headaches, and dizziness.

What Is Oleptro?

Oleptro™ (trazodone ER) is a prescription medication approved for the treatment of depression. It is a long-acting, once-daily version of an older depression medication.
(Click Oleptro Uses for more information, including possible off-label uses.)

Who Makes This Medication?

Oleptro is made by Labopharm Europe Limited.

How Does Oleptro Work?

It is not entirely clear how Oleptro works. There are no other medications that work exactly like it (other than the short-acting version of trazodone). It is known that Oleptro acts on a specific chemical within the brain known as serotonin. Serotonin is one of several chemicals used to send messages in between the nerves; but, when serotonin levels become unbalanced, it can cause a variety of conditions, including depression.
Oleptro helps to block the reuptake of serotonin (so that more serotonin is available for the nerves in the brain), which returns serotonin back to its "normal" levels. However, unlike selective serotonin reuptake inhibitors (SSRIs), trazodone may also block certain serotonin receptors.

Oleptro Effects

Studies have shown that Oleptro can significantly improve depression symptoms, compared to a placebo (a "sugar pill" with no active ingredients). Additionally, the antidepressant activity of trazodone has been well demonstrated in many clinical studies of the short-acting version of this medication.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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