Depression Home > Pamelor Drug Interactions

Pamelor interactions with other medications, such as anticholinergic medications, arrhythmia medications, or MAOIs, can cause the body to metabolize the medications differently than intended. Some of these drug interactions with Pamelor can increase the amounts of certain medications in the blood, increasing your risk of side effects or increasing your risk of a dangerous arrhythmia called QT prolongation. Your healthcare provider may need to adjust your dosage of these medications.

Pamelor Drug Interactions: An Introduction

Pamelor® (nortriptyline hydrochloride) can potentially interact with many medicines. Some of the medicines that may lead to Pamelor interactions include:
  • Barbiturates, including:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
  • Pressors, including:
    • Dopamine (Intropin®)
    • Dobutamine (Dobutrex®)
    • Epinephrine (Adrenalin®, EpiPen®)
    • Norepinephrine (Levophed®)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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